Abstract
To assess the role of maturity on the renal responses to asphyxia (Asph)16 spontaneously born term (T) and 5 preterm (PT)experimental and 12 control (C) lambs were studied between 1-6 days of age. We procured surviving PT lambs by induction of delivery at 133 days gestation with a fetal glucocorticoid injection. Asphyxia was induced by adding 38 ml/kg of dead space to the airway for 20 min. changing the arterial blood pH to 7.05 in the T, 7.17 in the PT, pO2 to 36 in the T and 29 torr in the PT and pCO2 to 66 in the T and 62 torr in the PT groups. The studies continued for 2 hrs. following the removal of the dead space. Plasma glucose concentrations increased significantly (peak:M±SE 285±50ml/dl) from baseline in the T during and for 15 min. after Asph. Excreted glucose increased and the percentage of tubular reabsorption of glucose decreased significantly (p<0.05), after Asph. Urine volumes, fractional and absolute sodium excretions, and osmolar clearances increased in the PT and T groups during Asph. and significantly (p<0.05) 30 min. after the removal of the dead space. No differences were observed between the PT and T groups when these changes were compared. GFR,total renal blood flow (microsphere technique),and plasma renin values did not change significantly during or after Asph. in either the T or PT groups. Changes were not seen in the C lambs. The data indicate that irrespective of maturity, Asph. produces significant hyperglycemia with concomitant natriuresis and osmotic diuresis.
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Stonestreet, B., Laptook, A., Siegel, S. et al. 1544 EFFECTS OF ASPHYXIA ON RENAL FUNCTION IN TERM AND PRETERM LAMBS. Pediatr Res 15 (Suppl 4), 700 (1981). https://doi.org/10.1203/00006450-198104001-01567
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DOI: https://doi.org/10.1203/00006450-198104001-01567