Abstract
Incomplete suppression of glucose production (GP) during exogenous glucose infusions has been reported in newborns within the first 3 hours of life (Ped. Res. 14:576, 1980) and in prematures (Ped. Res. 14:586, 1980). To further evaluate the effects of birth weight, gestational age, and postnatal age on this process, we infused eight infants with [6,6−2H2]glucose prior to and after beginning an infusion of exogenous glucose at a rate approximately equal to normal neonatal hepatic glucose output (5 mg kg-1-min-1). The study subjects ranged from gestational ages of 32-40 weeks, had birth weights between 1320 and 4140 grams, and were studied between 14 hours and 5 days after birth. None was hypoglycemic prior to or during the study. Basal GP averaged 5.02 ± 0.43 mg·kg-1 min-1. Exogenous glucose infusion produced incomplete suppression of GP in all infants averaging 50 ± 9% (range 3-72%). The degree of suppression did not correlate with gestational age, birthweight, or with postnatal age. However, there tended to be an inverse relationship between the degree of suppression of GP and the difference between the plasma glucose concentration before and after the exogenous glucose infusion. Thus, failure of complete suppression of GP in the newborn is present throughout the immediate postnatal period. Also, those infants with less suppression of GP tend to become more hyperglycemic during such infusions.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Leake, R., Waters, C., Karl, I. et al. 1352 INCOMPLETE SUPPRESSION OF NEONATAL GLUCOSE PRODUCTION BY EXOGENOUS GLUCOSE. Pediatr Res 15 (Suppl 4), 668 (1981). https://doi.org/10.1203/00006450-198104001-01381
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-01381