Abstract
The rate at which the systemic arterial blood pressure (SABP) is restored after asphyxial and hypotensive insults may be a factor in the pathogenesis of perinatal central nervous system lesions. To examine this, brain blood flow (BBF) was determined in 16 newborn piglets during asphyxia, superimposed hypotension and subsequent volume expansion (15 ml/kg, plasmanate). Asphyxia (A) was produced by a respiratory dead space and hypotension (H) by phelbotomy. Group 1 received plasmanate in 3 min., Group 2 in 30 min. and Group 3 received none. BBF (microsphere technique) was measured with each insult and at 5 and 30 min. after the start of the volume expansion and removal of the dead space. Results were (MĀ±SEM):
*p<.02 as compared to control, +p<.05 as compared to Group 3. SABP was reduced (p<.05) in Group 3 at 5 min. after A and H. All groups had significant reductions in hematocrit from control at the completion of the study. At autopsy, intracranial hemorrhage was not observed. The data indicate that 1) the rate of volume expansion did not influence the magnitude of BBF and 2) the higher BBF at the completion of volume expansion probably reflects compensation for anemia to achieve adequate oxygen delivery.
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Laptook, A., Stonestreet, B. & Oh, W. 1350 EFFECTS OF RATE OF VOLUME EXPANSION ON BRAIN BLOOD FLOW AFTER ASPHYXIA AND HYPOTENSION IN THE PIGLET. Pediatr Res 15 (Suppl 4), 668 (1981). https://doi.org/10.1203/00006450-198104001-01379
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DOI: https://doi.org/10.1203/00006450-198104001-01379