Abstract
We are studying the effect of a timed teratogenic event on cardiac morphogenesis. A 0.5 mm loop of 10-0 nylon was placed constricting the midpoint of the conotruncus in stage 24 chick embryos. The embryos were reincubated and harvested between stages 36 and 40. The embryo hearts were fixed in diastole, microdissected and measured. The study group included 46 experimental, 35 sham operated and 72 control embryos.
In 27 (59%) experimental embryos, the aorta arose from the right ventricle. In this group the separation of the mitral and aortic valve (MAS) (0.85 ± .06 mm) was significantly greater (p< .05) than sham operated and control embryos (0.34 ± .09 mm). MAS did not increase with developmental stage. All embryos with double outlet right ventricle had 1 or more ventricular septal defects and 7 (26%) had aortic arch malformations.
Among 15 embryos with the aorta originating from the left ventricle the MAS (.50 ± .05 mm) was not significantly different from controls. All but one embryo in this group had a ventricular septal defect and 6 (40%) had aortic arch malformations. Right ventricular size was similar among experimental, sham operated control embryos.
These data indicate a timed teratogenic insult to the conotruncus can interfere with the assignment of the aorta to the left ventricle resulting in double outlet right ventricle and the persistance of the aortic conus.
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Clark, E., Rosenquist, G. 1199 DOUBLE OUTLET RIGHT VENTRICLE FOLLOWING CONOTRUNCAL CONSTRICTION IN THE CHICK EMBRYO. Pediatr Res 15 (Suppl 4), 642 (1981). https://doi.org/10.1203/00006450-198104001-01225
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DOI: https://doi.org/10.1203/00006450-198104001-01225