Abstract
The minor hemoglobins, Hb AIa+b, are less well characterized than Hb AIc (the glucose adduct), but are probably adducts of phosphorylated hexoses. Hb AIc has been shown to reflect the integrated plasma glucose level over previous weeks. Minor hemoglobins, Hb AIa+b and Hb AIc, were measured by high-performance liquid chromatography (HPLC) in children and adults with insulin-dependent diabetes under variable control, glycogen storage diseases (I, IX) and fructose-1,6-diphosphatase deficiency.
Elevation of Hb AIc, which was lowered by dialysis, was only found in the diabetics (p <.001). In contrast, subjects with Type I GSD and Fructose-1,6-D'Pase deficiency had elevated Hb AIa+b (p <0.001), which was not altered by dialysis. Since these latter disorders are often associated with lactic acidosis and hypoglycemia, glycolytic intermediates in the red blood cells are likely adducts. Analysis of the individual minor hemoglobins may serve in the screening and management of these disorders.
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Zeller, W., Cornblath, M., Schwartz, H. et al. 1194 MINOR HEMOGLOBINS IN DISORDERS OF CARBOHYDRATE METABOLISM. Pediatr Res 15 (Suppl 4), 641 (1981). https://doi.org/10.1203/00006450-198104001-01220
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DOI: https://doi.org/10.1203/00006450-198104001-01220