Abstract
Previous studies characterized some of the mild morphologic and functional changes of the intestinal mucosa in apparently healthy young chileans belonging to the lowest socioeconomic strata. Absorption of glucose was studied by the marker-perfusion technique in 6 subjects.Infusion rate was 9.5 ml/min. The proximal sampling orifice was located under fluoroscopy at the ligament of Treitz and the distal sampling orifice was 30 cm aborally.Solutions with 18,36,75,100 or 150 mM of glucose,5mM of K and 1% PEG 4000 as marker,were perfused in random order. Sodium and chloride were added to adjust osmolality to 300.
These values can be plotted in a sigmoid-shaped curve and best represented by Hill's equation.K(or S0.5) is 41.7 mM. This is lower than reported values for individuals living in well-sanitated environments.Electrolytes and water were absorbed independently from glucose.Environmental enteropathy induces mild,non specific changes of small intestinal morphology and xylose,nitrogen and lipid absorption,as well as,glucose transport.
Supported by Nutrition Foundation and United Nations University
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Espinoza, J., Lois, I., Pacheco, I. et al. 7 Glucose absorption in subjects with environmental enteropathy (E.E.). Pediatr Res 15, 177 (1981). https://doi.org/10.1203/00006450-198102000-00027
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DOI: https://doi.org/10.1203/00006450-198102000-00027