Abstract
To compare intrafamilial associations among siblings(S) who still share and no longer share a common household environment, S-S correlations for total cholesterol(TC), high and low density lipoprotein cholesterol(C-HDL, C-LDL), and triglyceride(TG) were calculated.For the 54 black(B) and 230 white(W) adult(>20yrs old) (A) S-S pairs, and for the 97 B and 274 W child (6-19 yrs old)(C) S-S pairs, the correlations (*p<.02,**<.01,†<001) were:
There were no consistent B-W differences in lipid-lipoprotein correlations in A or C S-S pairs. S-S correlations for C-LDL, TC, and TG were either comparable or stronger in A S-S than in C S-S pairs, despite the loss of shared households in the A S-S pairs. This suggests a lasting and persistent influence of genetic factors on C-LDL and TG, or, speculatively, persistence into adulthood of shared environmental effects. In contrast, S-S correlations for C-HDL were stronger in C than in A S-S pairs, suggesting a substantial influence of environmental factors on C-HDL, revealed when common households are no longer shared. Explication of environmental factors which affect C-HDL might be realized by longitudinal studies of lipoproteins from childhood to adulthood.
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Morrison, J., Horvitz, R., Kelly, K. et al. 1166 LIPID AND LIPOPROTEIN CORRELATIONS IN BLACK AND WHITE ADULT AND CHILD SIB PAIRS. Pediatr Res 15 (Suppl 4), 637 (1981). https://doi.org/10.1203/00006450-198104001-01192
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DOI: https://doi.org/10.1203/00006450-198104001-01192