Abstract
Myocardial performance was assessed by M-mode echocardiography in 33 children (6 8/12-19 3/12 yr) with Type I diabetes mellitus and in 51 normal children (6 2/12-18 8/12). Left ventricular end systolic dimension (LVESD), and left ventricular end systolic volume/M2 (LVESV/M2) were greater in diabetics than controls. Left ventricular ejection fraction (LVEF), minor axis shortening (MAS), and velocity of circumferential fiber shortening (VCF) were less in diabetics than controls.
Hgb A1 levels in children with diabetes (15.5±0.6%, range 10.1-22.2%, normal 5.9-8.7%) correlated with clinical assessment of control (p<.01). Age, Hgb A1, duration of diabetes, and clinical assessment did not predict myocardial function. We conclude that there is impaired myocardial contractility in some children with insulin-dependent diabetes not correlated with duration of diabetes, age, clinical assessment of control, or Hgb A1. The long-term significance of this finding and the effect of improved control remain to be assessed.
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Friedman, N., Levitsky, L., Edidin, D. et al. 1121 ECHOCARDIOGRAPHIC EVIDENCE FOR IMPAIRED MYOCARDIAL PERFORMANCE IN CHILDREN WITH TYPE I DIABETES MELLITUS. Pediatr Res 15 (Suppl 4), 629 (1981). https://doi.org/10.1203/00006450-198104001-01147
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DOI: https://doi.org/10.1203/00006450-198104001-01147