Abstract
Monitoring of antibiotic resistance via disc diffusion or measurement of minimum inhibitory concentration is vital to optimal medical care. The compilation of these patterns of resistance and publication as antibiograms are essential in allowing physicians to intelligently administer proper antibiotic and drug regimens. We have monitored specific resistance rates plus trends of drug resistance in a children's hospital.
Of major importance is the decrease of ampicillin-sensitivity by multiple microorganisms including Hemophilus influenzae, salmonella, shigella species, and several gram-negative bacteria involved in pediatric urinary tract infections. In 1979, 78% of the H. influenzae isolates were sensitive to ampicillin, as opposed to 1977 when 82% were ampicillin-sensitive. Even greater changes were seen in the Shigella species, in 1973, 100% of S. flexneri were ampicillin-sensitive and by 1979 only 37% were sensitive. Escherichia coli has gone from 85% to 46% in the same time span. Gram-negative microorganisms have undergone similar patterns with gentamicin. Klebsiella and Enterobacteriaceae have gone from 100% sensitive to gentamicin in 1973 to only 62% and 58% respectively in 1979. Other antibiotics analyzed included: penicillins, semi-synthetic penicillins, cephalosporins, chloramphenicol, erythromycin, and trimethoprim/sulfamethoxazole. The use of pediatric antibiograms should be routine in pediatrics.
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Jacobs, R., Yamauchi, T. & Eisenach, K. 1032 ANTIBIOGRAMS – MONITORING ANTIBIOTIC RESISTANCE. Pediatr Res 15 (Suppl 4), 614 (1981). https://doi.org/10.1203/00006450-198104001-01058
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DOI: https://doi.org/10.1203/00006450-198104001-01058