Abstract
Parent-adult progeny(>20yrs old)(P-AP), and and parent-pediatric progeny (6-19 yrs old)(P-PP) correlations for plasma low and high density lipoprotein cholesterols(C-LDL,C-HDL) were assessed in randomly recalled white subjects in the LRC Princeton school family study to compare intrafamilial lipoprotein associations among family members still sharing and no longer sharing a common household environment. Father(F)-son(S), F-daughter(D),mother(M)-S, M-D C-LDL and C-HDL correlations in the 75 P-AP pairs and 245 P-PP pairs, (*p<.05, **p<01), were as follows:
For C-LDL, F-S and F-D relationships were significant and comparable for both P-AP and P-PP pairs; M-S and M-D C-LDL correlations were less consistent than for F-S or F-D, and were significant only for M-S in the P-PP pairs. For C-HDL, in contrast to C-LDL, there were no significant P-AP relationships. For C-HDL, in P-PP pairs, the M-S, M-D, and F-D relationships were significant. The general similarities in C-LDL relationships in P-AP and P-PP pairs, particularly in F-S and F-D, suggest a lasting genetic influence on C-LDL. The loss of significant P-AP C-HDL relationships, when compared to those in P-PP suggests a substantial differential environmental effect when common households are no longer shared.
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Morrison, J., Horvitz, R., Kelly, K. et al. 742 LIPOPROTEIN CORRELATIONS IN PARENTS AND THEIR ADULT AND PEDIATRIC PROGENY. Pediatr Res 15 (Suppl 4), 566 (1981). https://doi.org/10.1203/00006450-198104001-00765
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DOI: https://doi.org/10.1203/00006450-198104001-00765