Abstract
Summary: One-hundred twenty-five serum samples from 82 patients with juvenile rheumatoid arthritis (JRA) were studied for the presence of hidden rheumatoid factor (RF) in an effort to find a better serologic marker to define JRA. Hidden 19S IgM RF was detected by means of a hemolytic assay utilizing the IgM-containing fraction of serum. The IgM fraction was obtained after acid separation of serum on a Sephadex G-200 column. Hidden 19S IgM RF was present in 68% of patients with seronegative JRA with a mean titer of 1:63. The mean titer for the polyarticular JRA group was 1:83, for the pauciarticular JRA group, it was 1:32, and for the systemic type-onset JRA patients, it was 1:32. When disease was active, the mean titer for all JRA patients was 1:108, for the active polyarticular JRA group it was 1:119, for the active pauciarticular JRA, it was 1:97, and for the active systemic JRA patients, it was 1:64. All values were significant at the P ≤ 0.001 when compared to disease and normal controls.
The hemolytic assay for RF on the IgM-containing fraction of serum thus enhances the serologic capabilities of defining JRA.
Speculation: These studies showing the correlation of disease activity and the presence of hidden rheumatoid factor will aid in evaluating and following disease activity in juvenile rheumatoid arthritis.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moore, T., Dorner, R., Weiss, T. et al. Hidden 19S IgM Rheumatoid Factor in Juvenile Rheumatoid Arthritis. Pediatr Res 14, 1135–1138 (1980). https://doi.org/10.1203/00006450-198010000-00010
Issue Date:
DOI: https://doi.org/10.1203/00006450-198010000-00010
Keywords
This article is cited by
-
Separation and characterization of complement-fixing immune complexes in juvenile rheumatoid arthritis patients
Rheumatology International (1986)
-
IgG and IgM rheumatoid factor in active seronegative nodular rheumatoid arthritis and in children with benign rheumatoid nodules
Clinical Rheumatology (1982)