Abstract
It has been proposed that MC NS is due to a variety of causes including hypersensitivity to inhalants, drugs, insects' sting, and/or foods. To test the latter, a study was undertaken in patients with MC NS (defined clinically and/or by biopsy) resistant to or dependent on corticosteroids or with frequent relapses (as defined by ISKDC). A response to dietary manipulation (improvement or worsening) was defined as the presence of acute and marked changes in 24 hr proteinuria (within 5 days, lasting>48 hr, increased≥4 fold or decreased to≤1/4). Most patients had simultaneous changes in weight, edema, urine output and serum albumin. Prior to the study period, all medications were discontinued; subsequently, no corticosteroids or immunesuppressors were administered until discharge from the protocol. 24 patients (age range 2-13 years) were studied over a 5 year period (1974-1979). 12 patients (50%) completed the study and had a response most likely as the result of dietary manipulation. 8 patients had no significant changes and 4 had incomplete studies. In conclusion: (1) observed changes probably were not due to spontaneous remission or relapse; (2) some patients did improve with dietary manipulation and no medications; (3) results obtained suggest need for further study to identify MC NS patients who would improve with dietary manipulation; (4) further study also is required to attempt quantitation of changes and objective conclusions.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McLeod, T., Strauss, J., Zilleruelo, G. et al. FOOD MANIPULATION AND MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS). Pediatr Res 14, 1001 (1980). https://doi.org/10.1203/00006450-198008000-00169
Issue Date:
DOI: https://doi.org/10.1203/00006450-198008000-00169