Abstract
Ten infants with respiratory distress syndrome and large patent ductus arteriosus gestational ages 27-35 weeks, birth weights 0.9 2.0 kg., were treated with 0.2 mg.kg intravenous Indomethacintrihydrate (IND) given 3 times at 12 hourly intervals. Renal function studies were performed before (T-O), 24 hours (T-24) and 48 hours (T-48) after the first dose of IND. As shown below, the urine volumes (Uv) and glomerular filtration rates (GFR) decreased at T-24 but returned to normal at T-48. The fractional excretion of sodium (FENa%), urine sodium (UNa), and urine osmolarity (Uosm). were also reduced at T-24 but decreased even further at T-48, despite the normal GFR. There was no appreciable change in the values of serum sodium, serum osmolarity and free-water clearance (CH2O).
The calculated CH2O + CNa decreased and the CH2O/CH2O + CNa increased appreciably; they measure proximal and distal tubular resorption of sodium, respectively. Intravenous IND appears to produce increased resorption of sodium, decreased GFR and Uv. Increased Na absorption would explain the low urine sodium, and urine osmolarity. * = p <.05.
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John, E., Bhat, R., Vasan, J. et al. EFFECT OF INTRAVENOUS INDOMETHACIN ON RENAL FUNCTION PREMATURE INFANTS. Pediatr Res 14, 985 (1980). https://doi.org/10.1203/00006450-198008000-00072
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DOI: https://doi.org/10.1203/00006450-198008000-00072