Abstract
The clinical and immunologic features of a six-year-old girl with a lifelong history of severe atopic dermatitis, asthma, recurrent otitis media, staphylococcal infections and disseminated "cold" skin abscesses were reported. A cellular defect in neutrophil chemotaxis, hyperimmunoglobulinemia E, specific IgE antibodies against cow milk associated with T lymphocyte dysfunction were found. Moreover the patient lacked serum IgM and staphylococcal agglutinins. Other neutrophil functions as well as Complement fractions C3, C3PA and C4 were normal.Le vamisole therapy (2,5 mg/Kg three days weekly for three months) induced a markedly clinical improvement. The skin lesions and staphylococcal abscesses gradually resolved and the patient gained weight. After the therapy a significant enhancement of PMN chemotaxis and T Lymphocytic functions were demonstrated, while serum IgM and staphylococcal agglutinins were still absent.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Businco, L., Laurenti, F., Rossi, P. et al. Levamisole treatment in a case of Job's Syndrome: clinical and immunological results. Pediatr Res 13, 84 (1979). https://doi.org/10.1203/00006450-197901000-00087
Issue Date:
DOI: https://doi.org/10.1203/00006450-197901000-00087