Abstract
35 hypopituitary patients treated with HGH, 5 hypopituitary subjects before the start of HGH treatment and 15 short-normal children were studied. Informed consent of the parents was obtained. In all the subjects an OGTT and a continous IGTT were performed. Of the 35 subjects, 16 showing a normal OGTT were submitted to an insulin-induced hypoglycemia test during therapy and 1 month after suspension. All the short-normal and hypopituitary subjects not under treatment showed a normal OGTT, 4 of the treated patients had an abnormal OGTT. In the subjects treated with HGH the insulin secretion was significantly lower than that of the normal children (p<0.01) but not significantly different from that of the non-treated hypopituitary chil dren. A weekly significant difference (p<0.05) was evident between the minimum blood glucose reached during treatment and that found after treatment suspension.
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Cicognani, A., Pirazzoli, P., Bernardi, F. et al. Sensitivity to exogenous insulin and endogenous insulin release in hypopituitary non-hypoglycemic children treated with HGH. Pediatr Res 13, 1195 (1979). https://doi.org/10.1203/00006450-197910000-00091
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DOI: https://doi.org/10.1203/00006450-197910000-00091