Abstract
Plasma LH and FSH, basal (b) and after LHRH (p), testosterone (T), estradiol (E2), estrone (E1), androstenedione (Δ4A) and prolactin(PRL) were determined in 5 pubertal boys with G before, during and after 50 mg C daily for 56 days (d). Results (mean, SEM):
In conclusion, C increases gonadotropins and testicular steroids. In spite of higher E1 and E2, G is reduced in most patients. This may be due to a higher T/E2 ratio or interference of C with E2 at the receptor site. Supported by the Swiss National Science Foundation (Grants No. 3.883.077 and 3.901.077).
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Bucher, H., Zachmann, M., Torresani, T. et al. Studies in clomiphene (C) treated pubertal boys with gynecomastia (G). Pediatr Res 13, 1194 (1979). https://doi.org/10.1203/00006450-197910000-00086
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DOI: https://doi.org/10.1203/00006450-197910000-00086