Abstract
Graft-versus-Host disease (GvHD) is still a frequent complication in clinical marrow transplantation. Advances in immunology have delineated the caual role of thymus-derived (T) lymphocytes in GvH reactions. Attempts have been made to reduce T-cells by treating the bone marrow itself in vitro after preparation. Experimental studies of our group showed hat in mice an in vitro treatment of incompatible sonar cells with T-cell specific antibodies before transplantation could supress an otherwise lethal GvH-reaction completely. The GvH-reactive T-lymphocytes were removed by a specific xenogenic antiserum against T-cells which had been purified from antibodies cross reacting with hemopoietic stem cells by an extensive absorption procedure.
The present report will summarize the application of this principle to clinical bone marrow transplantation: A case of a 11 year old girl with a second elapse of common acute lymphoblastic leukemia was successfully transplanted after marrow incubation with anti-T-cell globulin.
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Haas, R., Netzel, B., Rodt, H. et al. 43 ANTIBODY TREATMENT OF MARROW GRAFT IN VITRO: A PRINZIPLE FOR PREVENTION OF GvH DISEASE. Pediatr Res 13, 955 (1979). https://doi.org/10.1203/00006450-197908000-00059
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DOI: https://doi.org/10.1203/00006450-197908000-00059