Abstract
Negative nitrogen balance impairs prognosis of severe neonatal diseasas especially RDS, in premature infants. We compared the effect of different 1 - amino - acid (AA)- carbohydrate mixtures on nitrogen balance, blood glucose (BG), plasma insulin (IRI), glucagon and human growth hormone (HGH). Three AA/carbohydrate mixtures were supplied each to 10 premature infants: I) AA 5 g/ sorbitol 5 g/ xylitol 5 g/100 ml, II) AA 5 g/100 ml, III) AA 5 g/ glucose 10 g/100 ml.
RESULTS: BG showes a mild elevation in group I, no change in II and a sharp rise up to 180 mg% after 60 min. in III. IRI corresponded well with continous levels between 10 and 20 uU/ml in I and II and a sharp rise up to 110 uU/ml in III 75 min. after starting infusion. Within 150 min. IRI returned to a basal level of 8 uU/ml. Glucagon was not affected in I and III. In II there was a peak of 273 pg/ml after 60 min. Plasma HGH was well stimulated in all groups with an average maximum of 43 ng/ml after 60 min., returning to evelated basal levels of 19 ng/ml after 150 min. Infants on 24 h-infusion with I showed a positive nitrogen balance within the first day.
CONCLUSION: AA-carbohydrate-infusions caused high endogenous HGH-levels in premature infants leading to positive nitrogen balance within the first 24 hours. Amino acids did not affect carbohydrate induced BG, insulin and glucagon reaction.
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Kleet, M., Wille, L. GFR NITROGEN BALANCE AND HORMONAL RESPONSE IN PREMATURE INFANTS UNDER PARENTERAL AMINO ACID/CARBOHYDRATE NUTRITION. Pediatr Res 13, 72 (1979). https://doi.org/10.1203/00006450-197901000-00016
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DOI: https://doi.org/10.1203/00006450-197901000-00016