Abstract
Association of hyponatremia (serum Na+ <130 meq/1) with variation of diet protein and electrolyte concentration was studied in 3 groups of 10 newborns (b.wt. <1500 gms, 21 AGA, 9 SGA) with the following protocols: I-SMA 20 kcal/oz (0.65 meq Na+ & 1.5 gm protein/100 ml); II-SMA 20 HP (0.65 meq Na+ & 2.1 gm protein/100ml) and III-SMA 27 kcal/oz (0.85 meq Na+ & 2.1 gm protein/100ml). Patients entered the study at mean 10.3 days and were fed 120-130 kcal/kg/d. Significant persistent hyponatremia did not occur although Group I-3 patients, Group II-5 patients, and Group III- 4 patients had one or more sporadic episodes with peak frequency Groups II & III at the 2nd & 3rd weeks of study.
No specific therapy was given for ↓Na+; rate of weight gain from start of study (gm/d) were: I-19.4, II-21.0, III-23.3. Increase of formula protein concentration had no significant effect on the incidence of ↓Na at the volume and calories utilized, weight gain was appropriate in all groups with Na intake of 1.13-1.28 meg/kg/d.
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Curran, J., Barness, L. 416 Effect of dietary protein concentration upon the OCCURRENCE OF HYPONATREMIA IN LOW BIRTHWEIGHT INFANTS. Pediatr Res 12 (Suppl 4), 433 (1978). https://doi.org/10.1203/00006450-197804001-00421
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DOI: https://doi.org/10.1203/00006450-197804001-00421