Abstract
A prospective study was designed to investigate the changing trend in neonatal septicemia (positive blood and/or CSF culture) for its type and incidence in our NICU. In neonates meeting the generally accepted clinical criteria for septicemia, blood and CSF cultures were obtained. During a 2-year period 68 were found to have septicemia. Three were excluded because of multiple congenital anomalies. The incidence of gram positive septicemia was the same as gram negative (48vs52%). Overall mortality was 29% with 23&35% mortality in gram positive and gram negative respectively. The predominant gram positive bacteria was beta-hemolytic S. group B (34%) followed by S. aureus (5%). The most common gram negative bacteria was E. coli (17%) followed by K. pneumoniae (14%), RGN (11%) & P. aeruginosa (8%). The 7 RGN septicemias were caused by Citrobacter diversus (3), Acinetobacter anitratus (1), H. parainfluenza (1), P. multicida (1) and S. marcescens (1). Considering that both K. pneumoniae and P. aeruginosa septicemia occurred in neonates with chronic lung disease while on respirator (12 of 13 pts), the group of RGN constitutes the 3rd most common cause of neonatal septicemia which was associated with meningitis in 43% of cases while overall meningitis was 19%. This study reveals a changing trend in neonatal septicemia with beta-hemolytic S. group B as the most common and the RGN bacterias as more significant pathogens than previously reported. Proper bacteriologic identification of the RGN and use of appropriate antibiotic therapy are emphasized.
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Modanlou, H., Ortiz, O., Henke, R. et al. 368 TREND IK NEONATAL BACTERIAL INFECTION AND THE INCI-DENCE OF RABE GRAM NEGATIVE (RGN) SEPTICEMIA. Pediatr Res 12 (Suppl 4), 425 (1978). https://doi.org/10.1203/00006450-197804001-00373
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DOI: https://doi.org/10.1203/00006450-197804001-00373