Abstract
Growth hormone (GH) secretion was monitored continuously over 24 hours in 23 children with IDD to investigate the hypothesis that GH secretion evaluated in a physiologic fashion reflects the degree of ambiant glycemia. A constant blood withdrawal system was used on ambulatory subjects who otherwise were maintained on their usual diabetic routine.
All of the subjects studied had long standing insulin dependency and none exhibited clinical or biochemical evidence of hypoglycemia during the study period. Eight normal children (NC) were similarly studied.
Examination of the diurnal pattern of GH secretion revealed no difference in number of secretion episodes or in the ratio of awake/asleep GH secretion. Despite the normal mean ICGH, considerable individual variation in GH levels in IDD was observed. An additional 13 patients with IDD, not included with these data because of hypoglycemia, also had a normal mean ICGH and comparably wide individual variation.
Conclusion: There is no direct relationship between GH secretion and the degree of hyperglycemia in IDD.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Winter, R., Traisman, H. & Green, O. 344 INTEGRATED CONCENTRATIONS OF GROWTH HORMONE (ICGH) AND GLUCOSE (ICG) IN INSULIN DEPENDENT DIABETES IDD. Pediatr Res 12 (Suppl 4), 421 (1978). https://doi.org/10.1203/00006450-197804001-00349
Issue Date:
DOI: https://doi.org/10.1203/00006450-197804001-00349