Abstract
The antiserum was produced according to a method published by GREAVES and coworkers. Cells reacting with the antiserum were labelled by indirect immunofluorescence. Blood, bone maarow and spinal fluid of different types of leukemia, other hematological disorders and infectious diseases were investigated. A significant positive reaction was observed only with ALL-cells of the PAS positive and the undifferentiated type. Leukemic cells of AML, AMML, AMOL, CLL, CML (adult and juvenile type), T-ALL as well as cells from Osteomyelofibrosis, Osteomyelosclerosis, idiopathic thrombocytopenic purpura, Panmyelopathy and from infectous diseases did not show any significant reaction with the antiserum. In some doubtful cases this highly specific serum was helpful in establishing the diagnosis of ALL as well as assuring central nervous system disease or early bone-marrow-relapse.
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Kabisch, H., Winkler, K., Stührk, H. et al. RABBIT ANTI-ALL SERUM: SPECIFITY AND CLINICAL SIGNIFICANCE. Pediatr Res 12, 68 (1978). https://doi.org/10.1203/00006450-197801000-00047
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DOI: https://doi.org/10.1203/00006450-197801000-00047