Abstract
Endocrine studies have been carried out on three children with excessive height associated with advanced bone age, acromegalic features and evidence of brain dysfunction in the form of mental retardation and an abnormal EEG (Sotos' syndrome). Two children, a girl aged 4 years and a boy aged 3 years, had hydrocephalus and in them there was a paradoxical rise of growth hormone in response to a glucose load and a high resting prolactin level which rose excessively with TRH stimulation but suppressed during an L dopa test. Neither showed clinical evidence of precocious puberty. The other, a boy of 7 years, without air encephalographic evidence of hydrocephalus, had completely normal endocrine test results. These results show that hypothalamic dysfunction may be demonstrable in Sotos' syndrome by the use of appropriate tests.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Smail, P., Forsyth, C. & Browning, M. Endocrine function in three children with Sotos' syndrome. Pediatr Res 12, 1099 (1978). https://doi.org/10.1203/00006450-197811000-00110
Issue Date:
DOI: https://doi.org/10.1203/00006450-197811000-00110