Abstract
Testosterone (T), androstenedione (A), dehydroepiandroste rone (DHA), DHA-sulfate (DHA-S), FSH and LH were measured in 45 girls with PP and 35 with PA. In PP, plasma levels, ng/ml, (x̄ ± sem) of T (0.14 ± 0.03) and A (0.47 ± 0.05) were higher than in normal girls of same age (p< 0.01) and not different from normal levels at stage P2 (respectively p > 0.4, p > 0.8). DHA (1.06 ± 0.12) was high in respect of age, but lower than normal P2 level (p< 0.01). DHA-S (65-720 ng/ml) was lower than in normal girls at P2 (p < 0.0001). FSH (2.2 ± 0.18 mIU/ml) and LH (1.19 ± 0.16 mIU/ml) did not differ from normal girls at P2. In PA, T (0.15 ± 0.02) and A (0.5 ± 0.05) were high in respect of age but not different from normal P2 levels (respectively p > 0.4, p > 0.8). DHA (2.78 ± 0.37) was higher than normal P2 level (p < 0.05) and far higher than in PP (p < 0.00001). DHA-S (212-3800 ng/ml) was also higher than in normal girls at P2 (p < 0.04). FSH (1.08 ± 0.14 mIU/ml) and LH (0.68 ± 0.07 mIU/ml) were lower than in normal girls at P2 (p < 0.01, p = 0.05). These results are consistent with a lack of adrenal maturation in PP and a lack of gonadotropic maturation in PA, suggesting that adrenal and ovarian pubertal maturations are relatively independant.
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Roger, M., Bompard, Y., Toublanc, JE. et al. Androgens and gonadotropins levels in precocious puberty (PP) and premature adrenarche (PA) in girls. Pediatr Res 12, 1090 (1978). https://doi.org/10.1203/00006450-197811000-00052
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DOI: https://doi.org/10.1203/00006450-197811000-00052