Abstract
Summary: The lipid profile, total cholesterol, triglycerides, and lipoproteins (β;-, pre-β;-, and α-) of cord blood, is presented for 419 black and white infants (94% of the eligible population) born during an 18-month period in Bogalusa, Louisiana. At birth, white neonates of both sexes had higher average levels than black neonates of total cholesterol and β;-lipoproteins. White girls among the four race-sex groups had the highest cord blood levels of total cholesterol, β;-ipoproteins, and α-lipoproteins. Neither stress at delivery, birth weight, socioeconomic status, nor season of the year had an observable effect on any of the lipid or lipoprotein levels. The magnitude and direction of the relationships between the respective lipids and lipoproteins in cord blood were similar to those we have observed in preschool and school-aged children in the same community. Total cholesterol was highly correlated with both β;-and α-lipoproteins; triglycerides were correlated with pre-β;-lipo-proteins but inversely with α-lipoproteins. These observations suggest that basic biochemical relationships are already established at birth.
Speculation: The lipid and lipoprotein levels in cord blood provide useful baseline data for evaluating the evolution of lipoprotein profiles in children. By elucidating those factors which serve as determinants of lipids and lipoproteins in cord blood, we may come closer to understanding the lipid regulatory mechanisms in the general population.
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Frerichs, R., Srinivasan, S., Webber, L. et al. Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study. Pediatr Res 12, 858–863 (1978). https://doi.org/10.1203/00006450-197808000-00011
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DOI: https://doi.org/10.1203/00006450-197808000-00011
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