Abstract
Interstitial edema, effusion and increased bronchovascular markings are seen in chest x-rays of infants with Type II RDS. The possible beneficial role of furosemide given during the first 4 hrs. after birth was therefore studied in 17 consecutive premature infants with Type II RDS randomly divided into 2 groups. Group I (9) was given furosemide, lmg/kg via umbilical catheter. Group II (8) did not receive diuretics. Diagnosis of Type II RDS was based on x-ray features and benign clinical courses. The mean±S.E. gestational age (32.8±.4 vs 34.8±1.1 wks), birth wt. (1.8±.1 vs 1.9±.2kg), and total 24-hr fluid intake (68.4±1.4 vs 74.1±6.2ml/kg) was similar in Group I and Group II respectively.
Infants in Group I had higher (p<.01) pH and lower (p<.05) PCO2 levels at 4-8 hrs than those in Group II. Urine output (ml/kg/24hrs) and weight loss (gm/kg of birth wt/24hrs) were significantly higher (p<.01) in Group I (46.6±5.5 and 15.8±4.8 respectively) than in Group II (19.9±1.1 and 1.1±1.4). Electrolytes, initial and at 24hrs, were normal in both groups. The data indicate that furosemide is an effective diuretic and may facilitate improvement of ventilation in prematures with Type II RDS.
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Yeh, T., Reveri, M., Lilien, L. et al. 1250 FUROSEMIDE IN PREMATURE INFANTS WITH TYPE II RDS. Pediatr Res 12 (Suppl 4), 572 (1978). https://doi.org/10.1203/00006450-197804001-01256
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DOI: https://doi.org/10.1203/00006450-197804001-01256