Abstract
Animal studies have shown that the development of pulmonary oxygen toxicity is enhanced in the hyperthyroid and delayed in the hypothyroid state. PSOD activity was studied in 5 E at 130 and 5 E at 140 days (d) gestation and compared to 5 Tx at 130 and 5 Tx at 140 d gestation. All Tx were surgically thyroidectomized at 95 to 99 d gestation.
Although the Tx lung contained an increase number of smaller sized cells compared to E, there was no change in cell number or size within the Tx or E groups from 130 to 140 d. The PSOD activity per cell was decreased in E from 130 to 140 d, but tended to increase in Tx. Thus, in E, PSOD activity per cell decreases with increasing gestational age. Hypothyroidism in the ovine fetus during the last trimester retards fetal lung growth and alters PSOD activity.
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Erenberg, A., Frank, L., Roberts, R. et al. 1178 PULMONARY SUPEROXIDE DISMUTASE (PSOD) ACTIVITY IN THE EUTHYROID (E) AND ATHYROTIC (Tx) OVINE FETUS. Pediatr Res 12 (Suppl 4), 560 (1978). https://doi.org/10.1203/00006450-197804001-01184
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DOI: https://doi.org/10.1203/00006450-197804001-01184