Abstract
Following release of unilateral ureteral occlusion (UUO), the adaptive changes which occur in the contralateral kidney have been poorly documented and the mechanisms involved in these compensatory changes are unknown. In the present study, rats were subjected to 24 hrs of UUO, and adaptive changes in the contralateral kidney were studied after relief of UUO.
Twenty-four hrs after release of UUO, the contralateral kidney had a massive increase in GFR (1020±63 μl/min/100gmBW) and RBF (4552±490 μl/min/100gmBW) compared to sham-operated controls (GFR 595±18; RBF 2745±275, P<0.001 for both). Similar but less impressive compensatory changes occurred in rats with unilateral nephrectomy or unrelieved UUO (GFR 712±39, RBF 3330±227, P<0.05). The infusion of indomethacin (10 mg/kg) completely eliminated the adaptive changes in rats with relieved UUO (GFR 592±63, RBF 2892±245, P<0.001) but had no effect on sham-operated controls (GFR 578±18, RBF 2801±313, P = NS).
These data indicate that impressive adaptive changes in GFR and RBF occur in the contralateral kidney 24 hrs after release of UUO. The inhibition of these compensatory changes by infusion of indomethacin suggests that the increase in GFR and RBF may be mediated via release of prostaglandins from the previously obstructed kidney.
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Upadhyaya, K., Siegel, N. 1108 AMELIORATION OF COMPENSATORY CHANGES AFTER RELEASE OF UNILATERAL URETERAL OCCLUSION. Pediatr Res 12 (Suppl 4), 548 (1978). https://doi.org/10.1203/00006450-197804001-01114
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DOI: https://doi.org/10.1203/00006450-197804001-01114