Abstract
Dilutional syndrome has been observed after mechanical ventilation and the role of AVP hypersecretion questioned. 17 PI with respiratory failure submitted to positive and expiratory pressure therapy were compared to 21 PI without pulmonary disease. Plasma (P.Osm), Urinary (U.Osm) and plasma AVP (radio-immunoassay) were determined and results were as follow
In conclusion : 1) AVP is significantly increased in PI submitted to mechanical ventilation and may be responsible for the differences in U.Osm between the 2 groups. Mean P.Osm are identical but patients with lower P.Osm have higher plasma AVP levels. 2) hyper-secretion of AVP may be responsible for the dilutional syndrome observed in PI ventilated under positive and expiratory pressure.
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Pomarede, R., Moriette, G., Relier, J. et al. Arginine Vasopressin (AVP) in plasma of premature infants (PI) treated by mechanical ventilation. Pediatr Res 12, 150 (1978). https://doi.org/10.1203/00006450-197802000-00027
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DOI: https://doi.org/10.1203/00006450-197802000-00027