Abstract
In the newborn ET has been utilized both therapeutically and prophylactically. In spite of frequent ETs done, no studies of platelet-white cell microaggregates (MA) which cause RDS in massively transfused adults have been examined in blood to be used for neonatal ET. The presence of MA in blood used for prophylactic ET may explain some of the discordant results of clinical trials. This study examined coagulation and MA by the Swank filtration pressure method (SFP) in fresh blood (FB), blood stored 96 hours, and buffy coat poor (BCP) reconstituted blood (RB) from 4-day-old packed cells and fresh frozen plasma. Mean results from the 15 units were:
The following, present in physiological amounts, showed no significant difference among the above 3 groups: AT-III activity, prothrombin time, prekallikrein, high molecular weight kininogen, and factors I, II, VII, IX, XII. Dacron wool filters which removed microaggregates without changing any of the above studies except reducing the platelet count can be used with stored blood or non-BCP-RB. Based on these in vitro studies, it was concluded that FB (<24 hrs.) or RB-BCP should be used for neonatal ET.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barnard, D., Chapman, R., Simmons, M. et al. CHOICE OF BLOOD FOR EXCHANGE TRANSFUSION (ET) IN THE NEONATE: IN VITRO STUDY OF COAGULATION FACTORS AND MICROAGGREGATES. Pediatr Res 11, 467 (1977). https://doi.org/10.1203/00006450-197704000-00581
Issue Date:
DOI: https://doi.org/10.1203/00006450-197704000-00581