Abstract
Hyperglycemia, is one of the complications of parenteral alimentation in LBW infants. The effectiveness of insulin administration to improve glucose disposal was evaluated in 7 infants (mean b.w. 1100 gms., mean gestation 29 wks) at age 5-14 days. At midpoint during a 4 hr constant glucose infusion (14 mg/Kg/min), a placebo (0.9% saline) was given (control); the next day, insulin (10 mU/Kg/min for 50 min) replaced the placebo (experimental).
Plasma insulin (I) increased during glucose infusion induced hyperglycemia. Exogenous insulin results in further increase in I with significant fall in plasma glucose (G) and glucose insulin ratio (G/I). G remained normal 2 hours following conclusion of the 4 hr study. Hyperglycemia in LBW infants can be abolished by insulin treatment allowing 20 gm/Kg/day of glucose intake as a caloric source.
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Pollak, A., Cowett, R., Schwartz, R. et al. EFFECTS OF EXOGENOUS INSULIN ON GLUCOSE DISPOSAL OF LOW BIRTH WEIGHT (LBW) INFANTS. Pediatr Res 11, 448 (1977). https://doi.org/10.1203/00006450-197704000-00473
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DOI: https://doi.org/10.1203/00006450-197704000-00473