Abstract
Cardiovascular effects of polycythemia and hypervolemia were studied in newborn dogs 1-25 days old using the radioactive microsphere reference organ technique. Group I puppies (n=6) were made polycythemic and hypervolemic by transfusion with packed RBC's. GrII, (n=5) hypervolemic alone by transfusion with an equivalent amount of whole blood and GrIII, (n=7) polycythemic alone by exchange transfusion with packed RBC's. In GrI, transfusion raised the Hct from 48 to 70* and Increased the viscosity by 75%*. Cardiac output (C.O.) (ml Kg−1 min−1) decreased from 242±14 to 156±19*. Mean BP and peripheral vascular resistance (R) also Increased*. There was a decrease in blood flow (ml g−1 min−1) to the GI tract from 1.3±.2 to .6±14**, due to an Increase in R. The %C.O. to the gut decreased from 18.2±4 to 12.4±2*. Cerebral blood flow decreased from .32±.05 to .22±.04* due to an increase in cerebral R*, despite an Increase in %C.O. there. Renal blood flow and renal R were not significantly altered. GrII had no slcnlfleant changes in C.O., its distribution nor flow to cerebrum, gut, and kidney. Gr III had a decrease in C.O.** and an increase in BP* and R*. GI blood flow decreased from 1.58±.12 to .92±.04** and cerebral flow from .32±.04 to .19±.04** but there was no redistribution of C.O. from the gut to the brain as in GrI. Renal blood flow was unchanged but renal R increased from 63.9±3.4 to 72.2±3* and %C.O. to the kidney increased**. Thus, hyperviscoslty reduces blood flow to the gut and brain and this reduction is not appreciably affected by accompanying hypervolemia. *p<.05 **p<.01
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Kotagal, U., Keenan, W., Reuter, J. et al. REGIONAL BLOOD FLOW IN POLYCYTHEMIA AND HYPERVOLEMIA. Pediatr Res 11, 394 (1977). https://doi.org/10.1203/00006450-197704000-00149
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DOI: https://doi.org/10.1203/00006450-197704000-00149