Abstract
Since previous studies have shown a protective effect of the administration of ATP-MgCl2 in shock, the present study was designed to determine the effect of the infusion of ATP-MgCl2 after 30 minutes of bilateral renal artery occlusion. Twenty-four hours later, animals who received no infusion or only MgCl2 had 1) reduced GFR (27S±80 or 377±32 μl/min/100gmBW vs 1091±36 control values, p < 0.01), 2) marked diuresis (6.1±0.7 or 12.3±2.5 μl/min/100gmBW vs 3.1±0.2 control, p < 0.01), and 3) increased proportional flow to the outer cortex (1.83±.04 or 1.93±.06 vs 1.68±.04 control, p < 0.01) which suggested that these rats were in the early recovery phase of post-ischemic acute renal failure. The animals who received ATP-MgCl2 had 1) improved GFR (784±60), 2) no diuresis (3.5±0.4), and 3) a normal pattern of cortical perfusion (1.70±.05) which suggested that these animals had an enhanced state of renal function compared to the no-infusion or MgCl2-only groups of rats.
These findings suggest that the infusion of ATP-MgCl2 after 30 minutes of renal artery occlusion either 1) ameliorated the effect of renal ischemia or 2) accelerated the recovery process following acute renal injury.
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Siegel, N., Osias, M. & Chaudry, I. AMELIORATION OF ACUTE RENAL FAILURE WITH ATP-MgCl2 INFUSION. Pediatr Res 11, 558 (1977). https://doi.org/10.1203/00006450-197704000-01127
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DOI: https://doi.org/10.1203/00006450-197704000-01127