Abstract
Since recent data have suggested that hlstologic improvement in MCGN may be associated with longtenn steroid therapy, 4 patients with well documented MCGN who had not received steroids or immunosuppressive agents were studied. A second renal biopsy (bx) was performed 3, 3, 4, and 5 years after the initial diagnosis (1st bx). On the 1st bx, all patients had diffuse mesangial proliferation, lobulation, and splitting of the basement membrane: one patient hed subendothelial deposits, one patient had no deposits, and 2 patients had mesangial/subepithelial deposits.
On the second bx, there were progressive changes only in the one patient with subendothelial deposits (i.e., increased proliferation and nodular sclerosis). In the other 3 patients, there were either no significant changes (one patient) or a decrease in the degree of mesangial hypercellularity/proliferation (2 patients). Interstitial fibrosis and mesangial sclerosis were seen on the 2nd bx in all 4 patients.
These data suggest that renal histologic improvement (i.e., decreased cellularity/proliferation) may occur in patients with MCGN who are untreated. However, the presence of interstitial fibrosis and mesangial sclerosis suggests that some irreversible changes have occurred.
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Siegel, N., Kashgarian, M. SEQUENTIAL HISTOLOGIC CHANGES IN UNTREATED MESANGIALCAPILLARY GLOMERULONEPHRITIS (MCGN). Pediatr Res 11, 557 (1977). https://doi.org/10.1203/00006450-197704000-01126
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DOI: https://doi.org/10.1203/00006450-197704000-01126