Abstract
55 Girls ages 3 to 16 years with recurrent urinary tract infections were randomly treated with sulphamethoxazole-trimethoprim (ST), Ampicillin (A), and Cephalexin (C) for 10 days. Criteria included two consecutive urine cultures-greater than 100,000 col. /ml., no history of allergy to Penicillin or sulfa, and bacteria sensitive to the assigned medication. Therapeutic success (Rx. Success) was defined as a sterile urine culture at the fourth day after completion of therapy. Recurrent infection (Rec. inf.) was defined as two consecutive positive urine cultures during the first 80 days following an initial documented therapeutic success. E. coli was the most common organism; found in 19/28 (67.8Z) in ST group, 15/17 (88.2%) in A group, and B/10 (80%) in C group.
The total Rec. Inf. rate was statistically significant (p<0.05) between groups ST and C.
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Luangnaruamitchai, M., Fennell, R., Walkar, R. et al. A COMPARATIVE SHORT COURSE TREATMENT FOR BACTERIURIA IN GIRLS WITH RECURRENT URINARY TRACT INFECTIONS WITH AMPICILLIN, CEPHALEXIN, AND SULFAMETHOXAZOLE-TRIMETHOPRIM. Pediatr Res 11, 554 (1977). https://doi.org/10.1203/00006450-197704000-01105
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DOI: https://doi.org/10.1203/00006450-197704000-01105