Abstract
L-carnosine and beta-alanine are taken up in renal epithelial cells by independent systems for each compound with specifity for dipeptides and beta-amino acids, respectively. The transport is found to be active and concentration-dependent. After uptake L-carnosine is hydrolysed and beta-alanine vigorously oxidised to CO2. The rates for uptake and intracellular metabolism are higher for the studied dipeptide than the free amino acid.
The data gained in this investigation reveal an effective system serving entry of dipeptide/s/ in kidney epithelial cells and extend the evidence for the segreation of amino acid and dipeptide transport. They also corroborate the findings of an membrane carrier specific for beta-amino compounds. Lastly cernosine is a surprisingly effective substrate for oxidative metabolism.
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Nützenadel, W., Scriver, C. TRANSPORT AND METABOLISM OF L-CARNOSINE AND BETA-ALANINE IN KIDNEY CORTEX SLICES OF THE RAT. Pediatr Res 9, 855 (1975). https://doi.org/10.1203/00006450-197511000-00018
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DOI: https://doi.org/10.1203/00006450-197511000-00018