Abstract
This set of experiments was designed to see : (1) the relative sensitivity of a number of androgens on the feedback inhibition of gonadotropins, (2) if there is any alteration in the magnitude of feedback inhibition with sexual maturation. Testosterone, dihydrotestosterone, 3α-androstanediol and androstenedione were given in one injection s.c. as 250 μg/100 g body weight at the ages 16, 23, 26, 35, 56, 65 and 90 days. 24 hrs later LH and FSH were measured. The results suggest, that(1) The 2 adrenal androgens DHA and Δ 4 have no suppressive action on the gonadotropins, (2) All potent androgens as T,DHT,3α-Adiol suppressed LH secretion the order being 3α-Adiol, DHT, T at the period of 26–35 days where maximum suppression was observed, (3) T and DHT both inhibited FSH in all ages in male rats, whereas 3α-Adiol was ineffective, (4) The inhibition of the gonadotropins was found to be age dependent with the same dose administered, (5) The same dose of androgens suppressed LH maximally at days 26 and 35. In younger animals the suppression was not as marked but significantly lower than seen in the older age groups, (6) For FSH the situation is not as clear as that for LH, but still comparable. T and DHT had bigger inhibition in premature animals than in adults.
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Rager, K., Eichner, M., Willmann, W. et al. STUDIES ON THE RELATIVE SENSITIVITY FOR ANDROGEN FEEDBACK INHIBITION IN RATS DURING SEXUAL MATURATION. Pediatr Res 9, 687 (1975). https://doi.org/10.1203/00006450-197508000-00122
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DOI: https://doi.org/10.1203/00006450-197508000-00122