Abstract
Gonadectomized adult guinea pigs show different sexual responses to administered sex steroids. After oestradiol benzoate (OB) and progesterone (P) treatment lordosis is shown (upon manual stimulation of the lumbar region, or when mounting attempts are made by a male) by females but not by males.
This response of. females is abolished by prenatal administration of the propionate of testosterone (TP) but not of 5 α-androstan-3α, 17β-diol (ADP) or of 5α-dihydrotestosterone (DHTP). Mounting behavior is stimulated by OB +P in both normal and prenatally (TP or ADP or DHTP) treated females but not in males DHTP was effective in males but in none of the female groups, while TP stimulated mounting in all categories.
CONCLUSION : None of the prenatal treatments abolished all of the sex differences in adult responsiveness to the various hormones.
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Ten Bosch, J. EFFECTS OF VARIOUS ANDROGENS ADMINISTERED TO PREGNANT GUINEA PIGS ON THEIR FEMALE OFFSPRING. Pediatr Res 9, 687 (1975). https://doi.org/10.1203/00006450-197508000-00120
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DOI: https://doi.org/10.1203/00006450-197508000-00120