Abstract
Growth records of 64 patients with chromosome constitution 45×0 have been analyzed. The extremely short stature of adults with this condition (142.5 cm) appears to be due to the cumulative effects of intrauterine growth failure, a gradual decline in height velocity during childhood and to the absence of a pubertal height spurt. Pubic hair appeared in 68% of the patients but was delayed both in relation to chronological age and to bone age. There was no evidence of a pubartal height spurt eycn in those children in whom cubic hair appeared.
Treatment with oestrogens in 18 patients caused development of secondary sex characteristics but did not effect final stature. The age of the patient when treatment was given was not of significance in affecting the final height of the patient.
The adult heights of 17 patients ware compared with those of their parents; a regression coefficient was found which was identical to that found in 51 normal girls, a roughly constant amount of height being lost through the chromosomal abnormality. This suggests that the genes whose action underlies the variation in adult height amongst the normal population must be located for the most part on the autosomes.
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Brook, C., Murset, G., Zachmann, M. et al. GROWTH IN CHILDREN WITH 45 XO TURNER'S SYNDROME. Pediatr Res 9, 686 (1975). https://doi.org/10.1203/00006450-197508000-00113
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DOI: https://doi.org/10.1203/00006450-197508000-00113