Abstract
Extract: Using a fluorescent method based on the ability of the thrombin and calcium-activated fibrin-stabilizing factor (factor XIII) to incorporate dansyl cadaverine into casein, measurements were made in plasma samples from 52 healthy neonates and 25 fetuses between the 17th and 24th gestational weeks. Forty healthy adults and 63 samples from pregnant women were used as controls. The measured values ranged from 3 to 21 units/ml of plasma for neonates and 1 to 14 for fetuses, compared with 7 to 42 for the adult normal and 3 to 15 for the pregnant women populations.
Speculation: It is conceivable that the relatively low fibrin-stabilizing factor activity during fetal life and immediately after birth, corresponding, respectively, to mean values of about 0.25 and 0.5 of that found in normal adults, may afford some safeguard against lasting coagulation damage.
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Henriksson, P., Hedner, U., Nilsson, I. et al. Fibrin-stabilizing Factor (Factor XIII) in the Fetus and the Newborn Infant. Pediatr Res 8, 789–791 (1974). https://doi.org/10.1203/00006450-197409000-00002
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DOI: https://doi.org/10.1203/00006450-197409000-00002
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