Abstract
During the past 6 years 381 children have presented to our department with hematuria. This report concerns 2 groups: A: 140 children with isolated gross and microscopic hematuria; B: 39 children with hematuria and proteinuria (excluding systemic lupus erythematosus (SLE) and poststreptococcal glomerulonephritis (GN). In group A biopsy was abnormal in 25/71. Focal GN and diffuse proliferative GN were the most frequent pathological changes (24/25) with fibrin seen by fluorescent antibody (FA) in 7/9. Determination of split products of fibrin (SPF), C′3, C′4 and serologic tests were not helpful in predicting an abnormal biopsy; however, periodic and isolated instances of elevated SPF were found (16/71). Urinary protein excretion and renal function have remained normal during follow-up. Five children (3 prior to renal biopsy) eventually developed renal calculi. In group B all biopsies were abnormal (39) including 23/31 with positive FA stains. Elevated SPF (10/34) and depressed C′3 (11/34) were associated with more severe renal structural and functional abnormalities. Increasing urinary protein (18/33), depressed GFR (15/39), and a concentrating defect (17/34) were noted during follow-up.
Isolated hematuria appears to be a benign condition in our department; however, hematuria associated with proteinuria may indicate significant underlying renal disease.
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Richard, G., Fennell, R., Garin, E. et al. CLINICOPATHOLOGICAL SIGNIFICANCE OF HEMATURIA WITH AND WITHOUT PROTEINURIA IN CHILDHOOD. Pediatr Res 8, 460 (1974). https://doi.org/10.1203/00006450-197404000-00720
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DOI: https://doi.org/10.1203/00006450-197404000-00720