Abstract
Children were divided by radiologic and clinical criteria into uncomplicated bacteriuria: first infection and recurrent infection, and complicated bacteriuria: pyelonephritis, obstructive abnormalities (primarily neurogenic bladders) and simple reflux. All patients were treated for 2 weeks at 50 mg/kgm/day followed by 4 weeks at half this dose. Successful therapy was defined as eradication of the initial organism with maintenance of sterile urine for 6 weeks. Ninety-three patients were treated for 136 episodes of bacteriuria with the most common organisms being E. coli (60%), Proteus (19%) and Klebsiella (14%). There were only 4 failures to eradicate the original organism (2.9%) and 38 recurrences with a resistant organism (27.8%). Pseudomonas was the most common organism to recur (19/38). Successful therapy included first infection (100%), recurrent uncomplicated (75.5%), simple reflux (69.2%), pyelonephritis (58.6%) and obstructive lesions (51.9%). Difference for success in therapy for complicated (58.9%) and uncomplicated bacteriuria (81%) was statistically significant (<.01), as were the differences between the first infection, recurrent uncomplicated and complicated bacteriuria. The differences between complicated groups were not significant. In summary, the staging of bacteriuria appears very important for predicting recurrence rate. Cephalexin was effective In eliminating sensitive organisms in any stage of bacteriuria.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fennell, R., Walker, R., Richard, G. et al. CEPHALEXIN THERAPY IN THE STAGES OF BACTERIURIA IN CHILDREN. Pediatr Res 8, 455 (1974). https://doi.org/10.1203/00006450-197404000-00688
Issue Date:
DOI: https://doi.org/10.1203/00006450-197404000-00688