Abstract
Thirty-nine infants were born to women receiving betamethasone for threatened premature (6-1.3 wks )delivery using the regime of Liggins. Infants over 27 wks and under 6 lbs whose mothers had been treated 24 or more hrs prior to delivery were matched with infants of similar weignt, gestational age(G.A.) and status of membrane rupture. There were no differences between control and study patients in sex ratio, clinic vs. private status, or antepartum bleeding. 11 treated and 5 control infants were delivered by section. 3 treated and no control mothers received alcohol. 25 in each group had ruptured membranes for median times of 75 hrs (treated)and 48 hrs(controls) Median time of drug administration was 70 hrs prior to delivery. Results were as follows:
Betamethasone at least 24 hrs prior to delivery appears effective in preventing RDS in infants under S lbs.& 34 weeks.
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Kennedy, J., Gellis, S. ANTEPARTUM BETAMETHASONE IN THE PREVENTION OF RESPIRATORY DISTRESS SYNDROME. Pediatr Res 8, 447 (1974). https://doi.org/10.1203/00006450-197404000-00644
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DOI: https://doi.org/10.1203/00006450-197404000-00644
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