Abstract
Polio virus is capable of growing within human cells, and not mouse cells, because human cells possess certain genes required by the polio virus for multiplication. Miller et al. have demonstrated that these polio “susceptibility genes” are probably on human chromosome 19, since human-mouse hybrid cells are susceptible to polio only as long as they possess chromosome 19. We have hybridized cells from a patient carrying an X/19 translocation with mouse cells deficient in the X-linked enzyme HGPRT. These hybrids selectively retain that portion of chromosome 19 which is attached to the piece of the X with the HGPRT locus. These hybrids are susceptible to polio virus Types 1, 2 and 3, even though they lack a portion (the distal part of the long arm) of chromosome 19. This is consistent with assignment of the polio susceptibility genes to this chromosome and suggests they may be confined to a limited region of the chromosome. The hybrid cell approach is generally applicable to the analysis of susceptibility genes for viruses of limited host range, some of which are currently under study.
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Gerald, P., Monedjikova, V. & Enders, J. GENES FOR SUSCEPTIBILITY TO VIRUSES. Pediatr Res 8, 424 (1974). https://doi.org/10.1203/00006450-197404000-00507
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DOI: https://doi.org/10.1203/00006450-197404000-00507