Abstract
We have described previously an increased sensitivity of immature rodents to HCP, a finding which may relate to the reported high incidence of suggestive neuropathological changes found in exposed low-birth-weight infants. This age-dependent sensitivity in rodents can be accounted for by slower elimination of HCP. In adult rats and mice, biliary excretion accounts almost quantitatively for elimination of 14C-HCP, with 98% of label in bile present as the monoglucuronide (HCP-G). HCP-G is identified by chemical and enzymatic hydrolyses, and mass spectral analysis. Elimination of HCP from plasma is 6-fold slower in 3-day-old animals, yet bile and small intestinal contents exhibit comparable concentrations of radioactivity. Surprisingly, in the neonate 90% of label in bile is HCP, not HCP-G. The radiolabel in livers from young and adult rodents is primarily HCP. Adult-type elimination and biliary compositions are approached by 2 weeks of age. These results are compatible with an important contribution of enterohepatic circulation to the overall pharmacokinetic profile of HCP in immature rodents. (Supported in part by the MRC of Canada.)
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Warner, M., Hales, B., Yang, H. et al. AGE-DEPENDENT ELIMINATION OF HEXACHLOROPHENE (HCP) IN NEONATAL RODENTS: POSSIBLE ROLE OF ENTEROHEPATIC RECIRCULATION. Pediatr Res 8, 366 (1974). https://doi.org/10.1203/00006450-197404000-00158
Issue Date:
DOI: https://doi.org/10.1203/00006450-197404000-00158