Abstract
Extract: Adenylate cyclase activity of lung homogenates from fetal and neonatal rabbits is considerably higher than that found in adult animals. This activity does not change significantly between 21 and 31 days postconception, but maturational changes are observed in responses of adenylate cyclase activity to incubation with epinephrine, glucagon, and NaF. Epinephrine stimulated adenylate cyclase activity at all ages studied, 21, 24, 27, 30 and 31 days postconception. NaF depressed adenylate cyclase activity at 21 and 24 days but thereafter stimulated it at 27, 30, and 31 days. Glucagon stimulated adenylate cyclase activity only after delivery. We conclude that hormonally mediated responses in formation of adenosine 3′, 5′-monophosphate (cyclic AMP) occur in the lung of the fetal animal.
Speculation: Adenylate cyclase may be important in regulating pulmonary phospholipid biosynthesis in fetal animals. Activity of adenylate cyclase can be augmented by epinephrine in fetal lung homogenates and may mediate growth of the lung or premature formation of pulmonary surface active phospholipids.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barrett, C., Sevanian, A. & Kaplan, S. Adenylate Cyclase Activity in Immature Rabbit Lung. Pediatr Res 8, 244–247 (1974). https://doi.org/10.1203/00006450-197404000-00005
Issue Date:
DOI: https://doi.org/10.1203/00006450-197404000-00005
Keywords
This article is cited by
-
Untersuchungen über Effekt und Wirkungsmechanismus des Beta-Sympathomimeticums Ritodrine auf Synthese und Freisetzung von Dipalmitoyl-Lecithin in der fetalen Kaninchenlunge
Archives of Gynecology (1979)
-
The endocrine control of embryonic lung maturation in the chicken
Anatomy and Embryology (1978)