Abstract
Plasma alanine (PA), immunoreactive insulin (IRI) and blood glucose (BG) levels were measured in newborns (NB) before any feeding and between 5 and 72 hours of life, 3 hours after glucose administration. At 4 hours of life, in 26 NB (birthweight (BW) : 2,620 to 4,060 g), BG was 52 ± 2 mg/100 ml (mean ± S.E.), PA 447 ± 19 μM, and IRI 3.5 ± 0.4 μU/ml. In 5 premature NB (BW : 1,600 to 2,450 g), BG was 45 ± 11, PA 318 ± 52 (p < 0.05, significantly different from normal NB), IRI 3 .1 ± 0 .5. In 9 small for gestational age (SFGA) NB, (BW : 1,530 to 2,490g), BG was 45 ± 5, PA 384 ± 12 (p < 0.01), IRI 3 ± 0.4. A significant correlation was observed in all NB between PA and BW (r : 0.390, p < 0.05) but not between the other parameters. After glucose administration (31 normal NB and 10 SFGA), BG and IRI were similar, PA was significantly lower in SFGA (250 ± 32 μM) than in normal NB (424 ± 19, p < 0.005). A similar correlation was observed between PA and BW (r : 0.386, p < 0.05). The data suggest that PA may be dependent upon the muscle mass.
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Sizonenko, P., Paunier, L., Zahnd, G. et al. Alanine, insulin and glucose levels in newborns. Pediatr Res 8, 918 (1974). https://doi.org/10.1203/00006450-197411000-00106
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DOI: https://doi.org/10.1203/00006450-197411000-00106
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