Abstract
Prostaglandin (PG) activity has been found in homogenates of human umbilical vessels (1). Indomethaoin inhibits the PG production and reduces the resting tone of human umbilical artery (HUA) strips (2). In the present study the motor responses of spiral HUA strips in Krebs solution to PGE1 and PGE2 and to two endoperoxide intermediates in the prostaglandin biosynthesis, i.e. prostaglandin G2 and prostaglandin H2 (3), were studied. PGE1 produced relaxation at 0, 1-3 μg/ml but contraction at 10-40 μg/ml. PGE2 (0, 04-20 μg/ml), PGG2 (0,001-0,4 μg/ml) and PGH2(0,001-0,4 μg/ml) produced contractions only within the concentration range used. The time lapse to reach the peak effect was consistently shorter for the endoperoxides than for PGE1 and PGE2. The results support the theory that local synthesis of prostaglandins might be an important mechanism in tone regulation of the human umbilical artery.
1. Karim, S.M.M. Br.J.Pharmacol. 29:230, 1967.
2. Tuvemo,T. & Wide,L. Prostagl. 4:689, 1973.
3. Hamberg,M., Svensson,J., Wakabayashi,T. & Samuelsson,B. Proo. Nat. Acad. Sci. 71:feb, 1974.
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Tuvemo, T., Strandberg, K., Hamberg, M. et al. Effects of prostaglandins E1 and E2 and prostaglandin endoperoxides on the isolated human umbilical artery. Pediatr Res 8, 908 (1974). https://doi.org/10.1203/00006450-197411000-00067
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DOI: https://doi.org/10.1203/00006450-197411000-00067