Abstract
In the first series of experiments exteriorization of foetuses was carried out in near-term guinea pigs. The experimental groups of exteriorized foetuses were: 1.Hypoxic /N2 in cap/, 2. asphyctic /temporary cord-clamping in utero/ and 3. controls. The spontaneous closure of the cord vessels, transplacental antipyrine transfer, acid-base balance and survival rate of the foetuses were followed. After induction of spontaneous breathing in the foetuses which remained connected with the placenta, the previousely closed vessels reopened and the placental circulation was restored under the effect of the N2- breathing. In postasphyctie foetuses the placental circulation persisted in spite of the breating of atmospheric air, resulting in a favorable effect on the survival rate. In the second series of experiments the reactivity of isolated human umbilical artery and rabbit central ear artery was studied. The ultrafiltrates of the serum of hypoxic newborns exerted a smaller pressor effect on the human umbilical artery than on the rabbit ear vessel, while the corresponding effect of the normal serum ultrafiltrate was higher on the umbilical artery. In conclusion, a humoral action of the blood of hypoxic-asphyctic newborns is assummed, which tends to preserve the placental circulation.
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Boda, D., Murányi, L., Eck, E. et al. Alterations of the placental circulation and of there activity of the umbilical artery in experimental hypoxia and asphyxia. Pediatr Res 8, 900 (1974). https://doi.org/10.1203/00006450-197411000-00034
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DOI: https://doi.org/10.1203/00006450-197411000-00034