Abstract
Extract: By micropuncture techniques and sweat collection under mineral oil, sweat from patients with cystic fibrosis of the pancreas (sweat-CFP) and from normal controls (sweat-N) was perfused for 7 min into ducts of single sweat glands in fingers of normal subjects. After pilocarpine stimulation, and after discarding the samples collected during the first 5 min, sweat of the infused gland was collected over a period of 40–80 min.
The results were as follows: at all flow rates and over the whole period of time, a significant increase was observed in the sodium concentration of the sweat. The mean sodium concentrations were 62.0 ± 18.0 SD mEq/liter after perfusion with sweat-CFP and 20.0 ± 7.0 SD mEq/liter after infusion of sweat-N (Fig. 2). The increase in potasium concentration seen after infusion of sweat-CFP (mean 19.9 ± 5.0 SD mEq/liter) compared with that seen after infusion of sweat-N (mean 9.0 ± 5.5 SD mEq/liter) was compatible with that observed in sweat-CFP (Fig. 3). In contrast to retrograde infusion, subcutaneous infiltration of normal glands with sweat-CFP had no effect on either sodium or potassium concentration.
Speculation: The results clearly prove the humoral transducibility of the electrolyte defect reported in CFP and make the existence of a net sodium transport-inhibiting factor in sweat-CFP even more probable. We speculate from these data the factor might be a derivative of the sweat glands themselves rather than a substance present in blood, or interstitial fluid, or both.
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Kaiser, D., Drack, E. & Rossi, E. Inhibition of Net Sodium Transport in Single Sweat Glands by Sweat of Patients with Cystic Fibrosis of the Pancreas. Pediatr Res 5, 167–172 (1971). https://doi.org/10.1203/00006450-197104000-00004
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DOI: https://doi.org/10.1203/00006450-197104000-00004
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